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Keep track of Closely (1)pentobarbital will decrease the extent or outcome of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead into a reduce in fentanyl plasma concentrations, deficiency of efficacy or, maybe, improvement of a